Metformin is one of the oldest and most commonly prescribed blood sugar-lowering drugs used in the treatment of diabetes mellitus.
Vitamin B12 is a water-soluble vitamin that’s essential for nerve conduction, mental functioning, DNA synthesis, and red blood cell formation. It’s readily available in animal products, including fish, meat, poultry, eggs, and milk and other dairy foods. The recommended daily amount of vitamin B12 for most adults is 2.4 micrograms (mcg).
A number of clinical studies have found an association between long-term use of metformin and depleted vitamin B12 levels. It discovered that taking metformin for a long time can cause serum Vitamin B12 deficiencies and could potentially lead to anemia.
A deficiency of vitamin B12 can affect mood and energy and even result in permanent and irreversible nerve damage, chronic fatigue, memory loss, confusion, mood changes, and eventually, even dementia.
If you take metformin, a yearly check of your vitamin B12 status can alert your healthcare provider to any dips in your levels that may be early signs of a deficiency.
Simple supplementation could potentially prevent an issue down the road.